Metastasis of mucinous adenocarcinoma of colon to the mandible: A case report
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Abstract
Metastatic disease to the oral cavity is rare, representing only 1-8% of oral malignancies, and involvement of the mandibular ramus is even less prevalent. This report is a unique case of metastatic adenocarcinoma of the colorectal to the mandible. Clinical presentation can be quite variable, and most often a primary malignancy is already known. Jawbone metastasis are a sign of disseminated malignant neoplasms, with poor prognosis and usually an indication for palliative therapy. The requirement for arrival at an appropriate and prompt diagnosis is crucial for determining the most appropriate treatment regimens and improved outcomes. The oral metastatic lesion may be the first indication of an undiscovered distant primary tumor, making timely evaluation and treatment critical from an oncologic perspective. Here we report a known case of mucinous adenocarcinoma of colon who was referred due to a mandibular lesion. Keywords: Mandible; Mucinous adenocarcinoma; Metastasis.
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2.Feo CF, Veneroni S, Santoru A, Cossu ML, Scanu AM, Ginesu GC, et al. Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report. Int J Surg Case Rep. 2021;78:99-102.
3.Hajiran A, Baker K, Jain P, Hashmi M. Case of an appendiceal mucinous adenocarcinoma presenting as a left adnexal mass. Int J Surg Case Rep. 2014;5(3):172-4.
4.Pan J, Fan Z. Mucinous adenocarcinoma of the abdomen. Int Wound J. 2019;16(4):1045-6.
5.Zachariades N. Neoplasms metastatic to the mouth, jaws and surrounding tissues. J Craniomaxillofac Surg. 1989;17(6):283-90.
6.Vähätalo K, Ekfors T, Syrjänen S. Adenocarcinoma of the pancreas metastatic to the mandible. Journal of Oral and Maxillofacial Surgery. 2000;58(1):110-4.
7.Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.
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9.Clausen F, Poulsen H. METASTATIC CARCINOMA OF THE JAWS. Acta Pathol Microbiol Scand. 1963;57:361-74.
10.Seoane J, Varela-Centelles P, López-Niño J, Vázquez I, Abdulkader I, García-Caballero T. Gingival mucinous adenocarcinoma of a minor salivary gland. J Periodontol. 2010;81(4):626-31.
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12.Lim SY, Kim SA, Ahn SG, Kim HK, Kim SG, Hwang HK, et al. Metastatic tumours to the jaws and oral soft tissues: a retrospective analysis of 41 Korean patients. Int J Oral Maxillofac Surg. 2006;35(5):412-5.
13.Razmara F, Sharifi R, Shabankareh G, Derakhshan S. Metastasis of Breast Cancer to the Mandibular Gingiva: Report of a Rare Case. Middle East Journal of Cancer. 2020;11(1):109-13.
14.Glaser C, Lang S, Pruckmayer M, Millesi W, Rasse M, Marosi C, et al. Clinical manifestations and diagnostic approach to metastatic cancer of the mandible. International Journal of Oral and Maxillofacial Surgery. 1997;26(5):365-8.
15.Rubin MM, Jui V, Cozzi GM. Metastatic carcinoma of the mandibular condyle presenting as temporomandibular joint syndrome. Journal of Oral and Maxillofacial Surgery. 1989;47(5):507-10.
16.Linkous CM, Welch JT. Metastatic malignant tumors of the jaws: Report of a case. Oral Surgery, Oral Medicine, Oral Pathology. 1974;38(5):703-7.
17.Zachariades N, Koumoura F, Vairaktaris E, Mezitis M. Metastatic tumors to the jaws: A report of seven cases. Journal of Oral and Maxillofacial Surgery. 1989;47(9):991-6.
18.Bhardwaj M, Gupta P. Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. J Cancer Res Ther. 2018;14(3):706-8.
19.Notani K, Iizuka T, Yamazaki Y, Henmi T, Sugiura C, Kohgo T, et al. Mucinous adenocarcinoma of probable minor salivary gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):738-40.
20.Terasaki M, Terasaki Y, Wakamatsu K, Takahashi M, Kunugi S, Urushiyama H, et al. A mucin-rich variant of salivary duct carcinoma with a prominent mucinous component, a tumor that mimics mucinous adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(3):e210-4.
21.Ide F, Mishima K, Tanaka A, Saito I, Kusama K. Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. Virchows Arch. 2009;454(1):55-60.
22.Derakhshan S, Rahrotaban S, Mahdavi N, Mirjalili F. Metastatic renal cell carcinoma presenting as maxillary lesion: Report of two rare cases. J Oral Maxillofac Pathol. 2018;22(Suppl 1):S39-s43.
23.Favareto SL, Pellizzon ACA, Lopes Pinto CA, Bertolli E, Castro DG. The Role of Radiation Therapy as an Adjuvant Treatment in Nodal Metastasis of Malignant Chondroid Syringoma. Cureus. 2020;12(11):e11360.
24.Sluiter NR, Rovers KP, Salhi Y, Vlek SL, Coupé VMH, Verheul HMW, et al. Metachronous Peritoneal Metastases After Adjuvant Chemotherapy are Associated with Poor Outcome After Cytoreduction and HIPEC. Ann Surg Oncol. 2018;25(8):2347-56.
25.Xu B, Shi H, Wang S, Wang P, Yu Q. Secondary chondrosarcoma in the mandibular condyle. Dentomaxillofac Radiol. 2011;40(5):320-3.
26.Peacock ZS, Afshar S, Lukas SJ, Kaban LB. Customized repair of fractured mandibular reconstruction plates. J Oral Maxillofac Surg. 2012;70(10):e563-73.
27.Khan SM, Gossweiler MK, Zunt SL, Edwards MD, Blanchard SB. Papillary squamous cell carcinoma presenting on the gingiva. J Periodontol. 2005;76(12):2316-21.
2.Feo CF, Veneroni S, Santoru A, Cossu ML, Scanu AM, Ginesu GC, et al. Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report. Int J Surg Case Rep. 2021;78:99-102.
3.Hajiran A, Baker K, Jain P, Hashmi M. Case of an appendiceal mucinous adenocarcinoma presenting as a left adnexal mass. Int J Surg Case Rep. 2014;5(3):172-4.
4.Pan J, Fan Z. Mucinous adenocarcinoma of the abdomen. Int Wound J. 2019;16(4):1045-6.
5.Zachariades N. Neoplasms metastatic to the mouth, jaws and surrounding tissues. J Craniomaxillofac Surg. 1989;17(6):283-90.
6.Vähätalo K, Ekfors T, Syrjänen S. Adenocarcinoma of the pancreas metastatic to the mandible. Journal of Oral and Maxillofacial Surgery. 2000;58(1):110-4.
7.Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.
8.De Benedittis M, Palmiotto A, Turco M, Petruzzi M, Cortelazzi R. Salivary mucinous adenocarcinoma of the mandible. Odontology. 2017;105(2):257-61.
9.Clausen F, Poulsen H. METASTATIC CARCINOMA OF THE JAWS. Acta Pathol Microbiol Scand. 1963;57:361-74.
10.Seoane J, Varela-Centelles P, López-Niño J, Vázquez I, Abdulkader I, García-Caballero T. Gingival mucinous adenocarcinoma of a minor salivary gland. J Periodontol. 2010;81(4):626-31.
11.Aniceto GS, Peñín AG, de la Mata Pages R, Montalvo Moreno JJ. Tumors metastatic to the mandible: Analysis of nine cases and review of the literature. Journal of Oral and Maxillofacial Surgery. 1990;48(3):246-51.
12.Lim SY, Kim SA, Ahn SG, Kim HK, Kim SG, Hwang HK, et al. Metastatic tumours to the jaws and oral soft tissues: a retrospective analysis of 41 Korean patients. Int J Oral Maxillofac Surg. 2006;35(5):412-5.
13.Razmara F, Sharifi R, Shabankareh G, Derakhshan S. Metastasis of Breast Cancer to the Mandibular Gingiva: Report of a Rare Case. Middle East Journal of Cancer. 2020;11(1):109-13.
14.Glaser C, Lang S, Pruckmayer M, Millesi W, Rasse M, Marosi C, et al. Clinical manifestations and diagnostic approach to metastatic cancer of the mandible. International Journal of Oral and Maxillofacial Surgery. 1997;26(5):365-8.
15.Rubin MM, Jui V, Cozzi GM. Metastatic carcinoma of the mandibular condyle presenting as temporomandibular joint syndrome. Journal of Oral and Maxillofacial Surgery. 1989;47(5):507-10.
16.Linkous CM, Welch JT. Metastatic malignant tumors of the jaws: Report of a case. Oral Surgery, Oral Medicine, Oral Pathology. 1974;38(5):703-7.
17.Zachariades N, Koumoura F, Vairaktaris E, Mezitis M. Metastatic tumors to the jaws: A report of seven cases. Journal of Oral and Maxillofacial Surgery. 1989;47(9):991-6.
18.Bhardwaj M, Gupta P. Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. J Cancer Res Ther. 2018;14(3):706-8.
19.Notani K, Iizuka T, Yamazaki Y, Henmi T, Sugiura C, Kohgo T, et al. Mucinous adenocarcinoma of probable minor salivary gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):738-40.
20.Terasaki M, Terasaki Y, Wakamatsu K, Takahashi M, Kunugi S, Urushiyama H, et al. A mucin-rich variant of salivary duct carcinoma with a prominent mucinous component, a tumor that mimics mucinous adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(3):e210-4.
21.Ide F, Mishima K, Tanaka A, Saito I, Kusama K. Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. Virchows Arch. 2009;454(1):55-60.
22.Derakhshan S, Rahrotaban S, Mahdavi N, Mirjalili F. Metastatic renal cell carcinoma presenting as maxillary lesion: Report of two rare cases. J Oral Maxillofac Pathol. 2018;22(Suppl 1):S39-s43.
23.Favareto SL, Pellizzon ACA, Lopes Pinto CA, Bertolli E, Castro DG. The Role of Radiation Therapy as an Adjuvant Treatment in Nodal Metastasis of Malignant Chondroid Syringoma. Cureus. 2020;12(11):e11360.
24.Sluiter NR, Rovers KP, Salhi Y, Vlek SL, Coupé VMH, Verheul HMW, et al. Metachronous Peritoneal Metastases After Adjuvant Chemotherapy are Associated with Poor Outcome After Cytoreduction and HIPEC. Ann Surg Oncol. 2018;25(8):2347-56.
25.Xu B, Shi H, Wang S, Wang P, Yu Q. Secondary chondrosarcoma in the mandibular condyle. Dentomaxillofac Radiol. 2011;40(5):320-3.
26.Peacock ZS, Afshar S, Lukas SJ, Kaban LB. Customized repair of fractured mandibular reconstruction plates. J Oral Maxillofac Surg. 2012;70(10):e563-73.
27.Khan SM, Gossweiler MK, Zunt SL, Edwards MD, Blanchard SB. Papillary squamous cell carcinoma presenting on the gingiva. J Periodontol. 2005;76(12):2316-21.
| Files | ||
| Issue | Vol 9, No 1 (Winter 2022) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/jcr.v9i1.11084 | |
| Keywords | ||
| Mandible Mucinous adenocarcinoma Metastasis | ||
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How to Cite
1.
Derakhshan S, Moradzadeh Khiavi M, Borhani H, Matloubi N. Metastasis of mucinous adenocarcinoma of colon to the mandible: A case report. J Craniomaxillofac Res. 2022;9(1):52-56.
