Reconstruction of alveolar defects with regenerative properties of adipose-derived stem cells
-
Mohammad Bayat
,
Sarvenaz Karimi Aval
,
Mohammad Hosein Amirzade
,
Abdolreza Mohamadnia
,
Naghmeh Bahrami
Abstract
Introduction: Loss of tissue and dysfunction of body organs due to injuries and diseases have caused serious health problems despite the vast advances in Medicien. Bone repair through tissue engineering is one of the most important areas of attention for specialists in a wide range of departments, including orthopedics and maxillofacial surgeries. Materials and Methods: This case-series describes efficient clinical applications of adipose-derived stem cells (AdSCs) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after hemi-mandibulectomy. Results: As the result, this approach represented a considerable amount of three-dimensional bone formation in presented cases. Regenerating this amount of resected bone tissue rehabilitates the patients and gives clinicians a sufficient amount of bone and opportunity to insert dental implants to retrieve patients’ function and aesthetic. Conclusion: The application of AdSCs can be considered as an efficient treatment for bone regeneration in large alveolar bone defects. Keywords: Alveolar bone reconstruction; Mesenchymal stem cell; Adipose-derived stem cells; Natural bovine bone mineral.
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10. Gimble J, Rad MR, Yao S. Adipose tissue–derived stem cells and their regeneration potential. Stem Cells in Craniofacial Development and Regeneration. 2013:241-58.
11. Khojasteh A, Hosseinpour S, Rad MR, Alikhasi M. Buccal Fat Pad–Derived Stem Cells in Three-Dimensional Rehabilitation of Large Alveolar Defects: A Report of Two Cases. Journal of Oral Implantology. 2019;45(1):45-54.
12. Sen M, Miclau T. Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions? Injury. 2007;38(1):S75-S80.
13. Goulet JA, Senunas LE, DeSilva GL, Greenfield MLV. Autogenous iliac crest bone graft: complications and functional assessment. Clinical Orthopaedics and Related Research®. 1997;339:76-81.
14. Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG. Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone. 2006;38(6):758-68.
15. Fujii T, Ueno T, Kagawa T, Sakata Y, Sugahara T. Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria. Microscopy research and technique. 2006;69(7):580-4.
16. Khojasteh A, Kheiri L, Behnia H, Tehranchi A, Nazeman P, Nadjmi N, et al. Lateral ramus cortical bone plate in alveolar cleft osteoplasty with concomitant use of buccal fat pad derived cells and autogenous bone: phase I clinical trial. BioMed Research International. 2017;2017.
17. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Critical Reviews™ in Biomedical Engineering. 2012;40(5).
18. Jurgens WJ, Oedayrajsingh-Varma MJ, Helder MN, ZandiehDoulabi B, Schouten TE, Kuik DJ, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell and tissue research. 2008;332(3):415-26.
19. Ahn HH, Kim KS, Lee JH, Lee JY, Kim BS, Lee IW, et al. In vivo osteogenic differentiation of human adipose-derived stem cells in an injectable in situ–forming gel scaffold. Tissue Engineering Part A. 2009;15(7):1821-32.
20. Al-Salleeh F, Beatty MW, Reinhardt RA, Petro TM, Crouch L. Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice. archives of oral biology. 2008;53(10):928-36.
21. Sándor GK, Tuovinen VJ, Wolff J, Patrikoski M, Jokinen J, Nieminen E, et al. Adipose stem cell tissue–engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice–level adipose stem cells for bone regeneration. Journal of Oral and Maxillofacial Surgery. 2013;71(5):938-50.
22. Thesleff T, Lehtimäki K, Niskakangas T, Mannerström B, Miettinen S, Suuronen R, et al. Cranioplasty with adipose-derived stem cells and biomaterial: a novel method for cranial reconstruction. Neurosurgery. 2011;68(6):1535-40.
23. Mesimäki K, Lindroos B, Törnwall J, Mauno J, Lindqvist C, Kontio R, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. International journal of oral and maxillofacial surgery. 2009;38(3):201-9.
2. Khojasteh A, Hosseinpour S, Rezai Rad M, Alikhasi M, Zadeh HH. Buccal fat pad‐derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory prospective clinical study. Clinical implant dentistry and related research. 2019;21(2):292-300.
3. Khojasteh A, Sadeghi N. Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular atrophy: a preliminary human study. International Journal of Oral and Maxillofacial Surgery. 2016;45(7):864-71.
4. Salehi-Nik N, Rezai Rad M, Kheiri L, Nazeman P, Nadjmi N, Khojasteh A. Buccal fat pad as a potential source of stem cells for bone regeneration: a literature review. Stem cells international. 2017;2017.
5. Rezai Rad M, Bohloli M, Akhavan Rahnama M, Anbarlou A, Nazeman P, Khojasteh A. Impact of tissue harvesting sites on the cellular behaviors of adipose-derived stem cells: implication for bone tissue engineering. Stem cells international. 2017;2017.
6. Khojasteh A, Nazeman P, Rad MR. Dental stem cells in oral, maxillofacial and craniofacial regeneration. Dental Stem Cells: Springer; 2016. p. 143-65.
7. Amanat M, Naghdi K, Saeedi Moghaddam S, Ahmadi N, Rezaei N, Saadat S, et al. The Trend of Interpersonal Violence Mortality at National and Provincial Levels in Iran From 1990 to 2015. Journal of interpersonal violence. 2019:0886260519883869.
8. Amirzade-Iranaq MH, Masoumi SMR. 174: etiology and patterns of facial fractures in Iran: a systematic review and meta-analysis. BMJ open. 2017;7(Suppl 1):bmjopen-2016-015415.174.
9. Motlagh MF, Bayat M, Naji S. Bone Allograft: An Option for Total Mandibular Reconstruction. Craniomaxillofacial Trauma & Reconstruction. 2017;10(04):306-13.
10. Gimble J, Rad MR, Yao S. Adipose tissue–derived stem cells and their regeneration potential. Stem Cells in Craniofacial Development and Regeneration. 2013:241-58.
11. Khojasteh A, Hosseinpour S, Rad MR, Alikhasi M. Buccal Fat Pad–Derived Stem Cells in Three-Dimensional Rehabilitation of Large Alveolar Defects: A Report of Two Cases. Journal of Oral Implantology. 2019;45(1):45-54.
12. Sen M, Miclau T. Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions? Injury. 2007;38(1):S75-S80.
13. Goulet JA, Senunas LE, DeSilva GL, Greenfield MLV. Autogenous iliac crest bone graft: complications and functional assessment. Clinical Orthopaedics and Related Research®. 1997;339:76-81.
14. Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG. Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone. 2006;38(6):758-68.
15. Fujii T, Ueno T, Kagawa T, Sakata Y, Sugahara T. Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria. Microscopy research and technique. 2006;69(7):580-4.
16. Khojasteh A, Kheiri L, Behnia H, Tehranchi A, Nazeman P, Nadjmi N, et al. Lateral ramus cortical bone plate in alveolar cleft osteoplasty with concomitant use of buccal fat pad derived cells and autogenous bone: phase I clinical trial. BioMed Research International. 2017;2017.
17. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Critical Reviews™ in Biomedical Engineering. 2012;40(5).
18. Jurgens WJ, Oedayrajsingh-Varma MJ, Helder MN, ZandiehDoulabi B, Schouten TE, Kuik DJ, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell and tissue research. 2008;332(3):415-26.
19. Ahn HH, Kim KS, Lee JH, Lee JY, Kim BS, Lee IW, et al. In vivo osteogenic differentiation of human adipose-derived stem cells in an injectable in situ–forming gel scaffold. Tissue Engineering Part A. 2009;15(7):1821-32.
20. Al-Salleeh F, Beatty MW, Reinhardt RA, Petro TM, Crouch L. Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice. archives of oral biology. 2008;53(10):928-36.
21. Sándor GK, Tuovinen VJ, Wolff J, Patrikoski M, Jokinen J, Nieminen E, et al. Adipose stem cell tissue–engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice–level adipose stem cells for bone regeneration. Journal of Oral and Maxillofacial Surgery. 2013;71(5):938-50.
22. Thesleff T, Lehtimäki K, Niskakangas T, Mannerström B, Miettinen S, Suuronen R, et al. Cranioplasty with adipose-derived stem cells and biomaterial: a novel method for cranial reconstruction. Neurosurgery. 2011;68(6):1535-40.
23. Mesimäki K, Lindroos B, Törnwall J, Mauno J, Lindqvist C, Kontio R, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. International journal of oral and maxillofacial surgery. 2009;38(3):201-9.
| Files | ||
| Issue | Vol 10, No 2 (Spring 2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v10i2.14050 | |
| Keywords | ||
| Alveolar bone reconstruction; Mesenchymal stem cell; Adipose-derived stem cells; Natural bovine bone mineral. | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Bayat M, Karimi Aval S, Amirzade MH, Mohamadnia A, Bahrami N. Reconstruction of alveolar defects with regenerative properties of adipose-derived stem cells. J Craniomaxillofac Res. 2023;10(2):46-51.
