Polymorphous Adenocarcinoma of the Palate: A Case Report
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Abstract
Polymorphous adenocarcinoma is an uncommon neoplasm of the salivary glands, exhibiting a strong predilection for the minor salivary glands. It is distinguished by its characteristic polymorphous histologic appearance, infiltrative growth pattern, and relatively low potential for metastasis. A 45-year-old male presented with pain and swelling in the posterior palate persisting for two months, accompanied by difficulty in mastication and swallowing. Intraoral examination revealed a well-defined, ovoid swelling on the right side of the palate, displaying a nodular surface and erythematous margins. An excisional biopsy was performed, and histopathological evaluation confirmed the diagnosis of polymorphous adenocarcinoma. Keywords: Polymorphous adenocarcinoma; Polymorphous low-grade adenocarcinoma; Salivary gland neoplasm.
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14. Paleri V., Robinson M., Bradley P. Polymorphous Low-Grade Adenocarcinoma of the Head and Neck. Curr. Opin. Otolaryngol. Head Neck Surg. 2008;6:163–169.
15. Fife T.A., Smith B., Sullivan C.A., Browne J.D., Waltonen J.D. Polymorphous Low-Grade Adenocarcinoma: A 17 Patient Case Series. Am. J. Otolaryngol. 2013;34:445–448.
2. Freedman P.D., Lumerman H. Lobular Carcinoma of Intraoral Minor Salivary Gland Origin. Oral Surg. Oral Med. Oral Pathol. 1983;56:157–165.
3. Mauceri R, Coppini M, Alecci G, Cordova A, Florena AM, Magro G, Toro C, Campisi G. Polymorphous Adenocarcinoma: A Systematic Review of the Literature and Presentation of Two Cases in a Less-Considered Anatomical Site. Cancers (Basel). 2024 Jan 3;16(1):220.
4. Wysocki P.T., Westra W.H., Sidransky D., Brait M. Advancing toward a Molecular Characterization of Polymorphous Low Grade Adenocarcinoma. Oral Oncol. 2017;74:192–193.
5. Siddharth Gupta et al. Polymorphous Low-grade Adenocarcinoma of the Palate: Report of a Case and Review of Literature. Int J Head Neck Surg, 2011;2(1):57-60 57
6. Chatura KR. Polymorphous low grade adenocarcinoma. J Oral Maxillofac Pathol 2015;19:77‑82.
7. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD. Retrospective study and review of polymorphous low‑grade adenocarcinoma. Laryngoscope 2006;116:2145‑9.
8. Fatahzadeh M. Palatal polymorphous low‑grade adenocarcinoma:Case report and review of diagnostic challenges. Arch Orofac Sci 2012;7:92‑100.
9. Jawanda MK, Narula R, Gupta S, Gupta P. Polymorphous adenocarcinoma: A case report along with its characteristics and diagnostic challenges. J Oral Maxillofac Pathol 2021;25:517‑22.
10. Zarbo RJ. Salivary gland neoplasia: A review for the practicing pathologist. Mod Pathol 2002;15:298‑323.
11. Darling MR, Schneider JW, Phillips VM. Polymorphous low‑grade adenocarcinoma and adenoid cystic carcinoma: Areview and comparison of immunohistochemical markers. Oral Oncol 2002;38:641‑5.
12. Zhu S, SchuerchC, HuntJ. Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. Arch Pathol Lab Med 2015;139:55‑66.
13. Kaur P., Khurana A., Gupta S., Chauhan A. Polymorphous Low-Grade Adenocarcinoma of Base of the Tongue: A Case Report and Review of Literature of an Orphan Disease. Int. J. Head Neck Surg. 2020;11:71–74.
14. Paleri V., Robinson M., Bradley P. Polymorphous Low-Grade Adenocarcinoma of the Head and Neck. Curr. Opin. Otolaryngol. Head Neck Surg. 2008;6:163–169.
15. Fife T.A., Smith B., Sullivan C.A., Browne J.D., Waltonen J.D. Polymorphous Low-Grade Adenocarcinoma: A 17 Patient Case Series. Am. J. Otolaryngol. 2013;34:445–448.
| Files | ||
| Issue | Vol 13, No 2 (Spring 2026) | |
| Section | Case Report(s) | |
| Keywords | ||
| Polymorphous adenocarcinoma; Polymorphous low-grade adenocarcinoma; Salivary gland neoplasm. | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Abbas R, Hamid Latoo S. Polymorphous Adenocarcinoma of the Palate: A Case Report. J Craniomaxillofac Res. 2026;2026(2):246-250.
