Fibrolipoma: A Rare Oral and Maxillofacial Entity: A Case Report
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Abstract
Lipomas are the most common benign soft tissue tumors, but they occur only rarely in the oral cavity. Fibrolipoma, an uncommon variant, features mature adipose tissue with a prominent fibrous component, presenting as a slow-growing, asymptomatic mass. This article reports a rare case of hard palate fibrolipoma in a 73-year-old male, initially appearing as a small, asymptomatic, sessile nodule clinically suspected to represent a benign palatal lesion, including irritation fibroma, pleomorphic adenoma, mucocele, and lymphoepithelial cyst. Surgical excision was performed, with histopathology confirming fibrolipoma. No recurrence was observed during 20 months of clinical follow-up. Fibrolipoma of the hard palate is exceptionally rare and may present a diagnostic challenge because of its nonspecific clinical appearance. Histopathological examination remains essential for definitive diagnosis, and complete surgical excision is associated with an excellent prognosis and a very low risk of recurrence. Keywords: Lipoma; Fibrolipoma; Oral mucosa; Hard palate; Oral neoplasm.
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2. Manjunatha BS, Pateel GD, Shah V. Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature. Journal of Dentistry (Tehran, Iran). 2010 Sep 30;7(4):226.
3. Chi TH, Tsao YH, Yuan CH, Lo HC, Chang JL. Fibrolipoma of the Hard Palate: A Case Report.
4. Mandal M, Panchal A, Kumar R, Kapadia P, Parmar N. Rare case of intra-oral palatal (soft palate) fibro-lipoma. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2021 Jan 14;7(5):885-7.
5. Torsakul P, Rirattanapong P, Phimonsri R. Fibroepithelial hyperplasia and fibrolipoma in a 4-year-old patient: a rare case report. Mahidol Dental Journal. 2024 Aug 2;44(2):113-20.
6. Hayashi K, Yamada S, Onda T, Shibahara T. A case of fibrolipoma of the hard palate. The Bulletin of Tokyo Dental College. 2020;61(1):53-60.
7. Devi AN, Sowbhagya MB, Balaji P, Kumar TM. An uncommon case of fibrolipoma. Indian Journal of Dental Research. 2017 Nov 1;28(6):699-701.
8. Vazirani SJ, DeVore DT. Fibrolipoma of the oral cavity: Report of a case. Oral Surgery, Oral Medicine, Oral Pathology. 1958 Apr 1;11(4):355-8.
9. Pellegrini M, Ghizzoni M, Pulicari F, Kuhn E, Scribante A, Spadari F. Diode Laser Treatment for Buccal Mucosa Fibrolipoma in an Elderly Patient on Anticoagulants: Case Report and Literature Review. Case Reports in Dentistry. 2025;2025(1):8847648.
10. Zhao G, Wang G, Lubamba GP, Bao M, Li C, Gao N. Review of Hard Palate Lipoma and Retrospective Clinicopathological Analysis of Patients With Oral Lipomas. Journal of Craniofacial Surgery. 2025 May 1;36(3):943-6.
11. Alomari F, Al Zayer ZH, Alferdous HM. Multiple Fibrolipomas of the Tongue: A Rare Case Report of a Pediatric Patient With Whole Exome Sequencing of the C2CD3 Gene. Case Reports in Dentistry. 2024;2024(1):5923373.
12. Wang D, Yu H, Gao T, Lu H, Wang YE. Fibrolipoma of the lower lip: A case report and review of the literature. Medicine. 2024 Jun 21;103(25):e38543.
13. Zouaghi H, Chokri A, Bouguezzi A, Abdeljelil NB, Sioud S, Hentati H, Selmi J. Oral fibrolipoma. Autopsy and Case Reports. 2023 May 8;13:e2023431.
14. Tandon A, Srivastava A, Jaiswal R, Gaur A. Oral fibrolipoma: A rare clinicopathological entity. Journal of Oral and Maxillofacial Pathology. 2023 Jul 1;27(3):537-9.
15. Mansoor S, Yaqoob N, Haneef A, Sham S, Arain AA. Fibrolipoma of tongue: a rare entity. J Coll Physicians Surg Pak. 2022 Jun 1;32(6):814-6.
16. Rezazadeh F, Jaafari‐Ashkavandi Z, Afshari A, Tarjan A. Rare fibrolipoma of attached gingiva: A case report and review of the literature. Clinical Case Reports. 2022 Nov;10(11):e6643.
17. Chhetri P, Nandini DB, Singh KS, Banerjee S. Fibrolipoma of the buccal mucosa in a geriatric patient. Journal of Microscopy and Ultrastructure. 2022 Oct 1;10(4):204-7.
18. Jin YT, Hwang MJ, Sun A, Chiang CP. Bilateral fibrolipomas at both lower retromolar pads–case report. Journal of Dental Sciences. 2020 Dec 9;16(2):786.
19. Salih AM, Abdullah AM, Fatah ML, Abdulla BA, Mohammed SH. Fibrolipoma of the tongue; a case report with literature review. Annals of Medicine and Surgery. 2021 Dec 1;72:102985.
20. Atarbashi-Moghadam S, Lotfi A, Mehdizadeh M, Atarbashi-Moghadam F. Clinicoradiographic features and histopathologic variations of intraosseous lipoma: report of a case and review of the literature. Case Reports in Dentistry. 2021;2021(1):2073001.
21. Wu YH, Kuo YS, Lin PY, Chiang CP. Oral fibrolipoma–Case report. Journal of Dental Sciences. 2020 Apr 4;15(2):227.
22. Phulari RG, Soni V, Talegaon TP, Bakutra G. Oral fibrolipoma: A report of two cases and review of literature. Indian Journal of Dental Research. 2018 Jul 1;29(4):513-6.
23. Pippi R, SaNtoRo M, PatINI R. Fibrolipoma of the oral cavity: Treatment choice in a case with an unusual location. Journal of Clinical and Diagnostic Research: JCDR. 2017 May 1;11(5):ZJ07.
24. Iaconetta G, Friscia M, Cecere A, Romano A, Orabona GD, Califano L. Rare fibrolipoma of the tongue: a case report. Journal of medical case reports. 2015 Aug 21;9(1):177.
25. Fomete B, Adebayo ET, Ononiwu CN, Idehen KO. Giant neurofibrolipoma of the tip of the tongue: case report and review of the literature. Annals of African medicine. 2014 Sep 4;13(1):50-2.
26. Pereira T, Shetty S, Sapdhare S, Tamgadge A. Oral fibrolipoma: A rare histological variant. Indian Journal of Dental Research. 2014 Sep 1;25(5):672-4.
2. Manjunatha BS, Pateel GD, Shah V. Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature. Journal of Dentistry (Tehran, Iran). 2010 Sep 30;7(4):226.
3. Chi TH, Tsao YH, Yuan CH, Lo HC, Chang JL. Fibrolipoma of the Hard Palate: A Case Report.
4. Mandal M, Panchal A, Kumar R, Kapadia P, Parmar N. Rare case of intra-oral palatal (soft palate) fibro-lipoma. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2021 Jan 14;7(5):885-7.
5. Torsakul P, Rirattanapong P, Phimonsri R. Fibroepithelial hyperplasia and fibrolipoma in a 4-year-old patient: a rare case report. Mahidol Dental Journal. 2024 Aug 2;44(2):113-20.
6. Hayashi K, Yamada S, Onda T, Shibahara T. A case of fibrolipoma of the hard palate. The Bulletin of Tokyo Dental College. 2020;61(1):53-60.
7. Devi AN, Sowbhagya MB, Balaji P, Kumar TM. An uncommon case of fibrolipoma. Indian Journal of Dental Research. 2017 Nov 1;28(6):699-701.
8. Vazirani SJ, DeVore DT. Fibrolipoma of the oral cavity: Report of a case. Oral Surgery, Oral Medicine, Oral Pathology. 1958 Apr 1;11(4):355-8.
9. Pellegrini M, Ghizzoni M, Pulicari F, Kuhn E, Scribante A, Spadari F. Diode Laser Treatment for Buccal Mucosa Fibrolipoma in an Elderly Patient on Anticoagulants: Case Report and Literature Review. Case Reports in Dentistry. 2025;2025(1):8847648.
10. Zhao G, Wang G, Lubamba GP, Bao M, Li C, Gao N. Review of Hard Palate Lipoma and Retrospective Clinicopathological Analysis of Patients With Oral Lipomas. Journal of Craniofacial Surgery. 2025 May 1;36(3):943-6.
11. Alomari F, Al Zayer ZH, Alferdous HM. Multiple Fibrolipomas of the Tongue: A Rare Case Report of a Pediatric Patient With Whole Exome Sequencing of the C2CD3 Gene. Case Reports in Dentistry. 2024;2024(1):5923373.
12. Wang D, Yu H, Gao T, Lu H, Wang YE. Fibrolipoma of the lower lip: A case report and review of the literature. Medicine. 2024 Jun 21;103(25):e38543.
13. Zouaghi H, Chokri A, Bouguezzi A, Abdeljelil NB, Sioud S, Hentati H, Selmi J. Oral fibrolipoma. Autopsy and Case Reports. 2023 May 8;13:e2023431.
14. Tandon A, Srivastava A, Jaiswal R, Gaur A. Oral fibrolipoma: A rare clinicopathological entity. Journal of Oral and Maxillofacial Pathology. 2023 Jul 1;27(3):537-9.
15. Mansoor S, Yaqoob N, Haneef A, Sham S, Arain AA. Fibrolipoma of tongue: a rare entity. J Coll Physicians Surg Pak. 2022 Jun 1;32(6):814-6.
16. Rezazadeh F, Jaafari‐Ashkavandi Z, Afshari A, Tarjan A. Rare fibrolipoma of attached gingiva: A case report and review of the literature. Clinical Case Reports. 2022 Nov;10(11):e6643.
17. Chhetri P, Nandini DB, Singh KS, Banerjee S. Fibrolipoma of the buccal mucosa in a geriatric patient. Journal of Microscopy and Ultrastructure. 2022 Oct 1;10(4):204-7.
18. Jin YT, Hwang MJ, Sun A, Chiang CP. Bilateral fibrolipomas at both lower retromolar pads–case report. Journal of Dental Sciences. 2020 Dec 9;16(2):786.
19. Salih AM, Abdullah AM, Fatah ML, Abdulla BA, Mohammed SH. Fibrolipoma of the tongue; a case report with literature review. Annals of Medicine and Surgery. 2021 Dec 1;72:102985.
20. Atarbashi-Moghadam S, Lotfi A, Mehdizadeh M, Atarbashi-Moghadam F. Clinicoradiographic features and histopathologic variations of intraosseous lipoma: report of a case and review of the literature. Case Reports in Dentistry. 2021;2021(1):2073001.
21. Wu YH, Kuo YS, Lin PY, Chiang CP. Oral fibrolipoma–Case report. Journal of Dental Sciences. 2020 Apr 4;15(2):227.
22. Phulari RG, Soni V, Talegaon TP, Bakutra G. Oral fibrolipoma: A report of two cases and review of literature. Indian Journal of Dental Research. 2018 Jul 1;29(4):513-6.
23. Pippi R, SaNtoRo M, PatINI R. Fibrolipoma of the oral cavity: Treatment choice in a case with an unusual location. Journal of Clinical and Diagnostic Research: JCDR. 2017 May 1;11(5):ZJ07.
24. Iaconetta G, Friscia M, Cecere A, Romano A, Orabona GD, Califano L. Rare fibrolipoma of the tongue: a case report. Journal of medical case reports. 2015 Aug 21;9(1):177.
25. Fomete B, Adebayo ET, Ononiwu CN, Idehen KO. Giant neurofibrolipoma of the tip of the tongue: case report and review of the literature. Annals of African medicine. 2014 Sep 4;13(1):50-2.
26. Pereira T, Shetty S, Sapdhare S, Tamgadge A. Oral fibrolipoma: A rare histological variant. Indian Journal of Dental Research. 2014 Sep 1;25(5):672-4.
| Files | ||
| Issue | Vol 13, No 2 (Spring 2026) | |
| Section | Case Report(s) | |
| Keywords | ||
| Lipoma; Fibrolipoma; Oral mucosa; Hard palate; Oral neoplasm. | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mirhosseini Y, Tonkaboni A, Aminshakib P. Fibrolipoma: A Rare Oral and Maxillofacial Entity: A Case Report. J Craniomaxillofac Res. 2026;2026(2):257-266.
